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KMID : 0377519890140040367
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Chung-Ang Journal of Medicine
1989 Volume.14 No. 4 p.367 ~ p.377
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Immunohistochemical Studies on the Polypeptide Hormones and Amine in the Adenocarcinoma of Stomach and Colon
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Abstract
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In order to study the distribution pattern and histogenesis of endocrine cells containing several polypeptides and amine of gastric and colonic adenocarcinoma, I performed immunoperoxidase staining for gastrin, somatostatin, glucagon, pancreatic polypeptide and serotonin respectively in 30 cases of surgically resected gastric carcinoma and 20 cases of surgically resected colonic carcinoma.
The results were as follws:
1. The positive cells of four polypeptides and amine are more abundant in the nonneoplastic glands than those in the neoplastic lesions.
2. The positive reaction of endocrine cells are variable in two neoplastic lesion. No serotonin positive cells in gastric adenocarcinoma and no gastrin positive cells in colonic adenocarcinoma are demonstrable.
3. The presence of more than one hormone is frequently demonstrable in the nonneoplastic glands rather than those in the neoplastic glands of two adenocarcinomas.
4. The positive reaction of endocrine cells of the neoplastic lesion in stomach depends upon the
differentiation of tumor cells, showing stronger reaction in the more differentiated type.
5. Therefore, according to the pattern of several polypeptides and amine positive cells in the gastric
and colonic adenocarcinoma, it is suggested that gastrointestinal endocrine cells are supposed
to be arised from the precursor cells of endodermal origin.
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